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Neoadjuvant Administration of MDNA11, A Long-Acting IL-2 Superkine, Prevents Metastasis, Protects Against Tumor Rechallenges and Provides Long-Term Survival in an Orthotopic Model of Breast Cancer

Neoadjuvant Administration of MDNA11, A Long-Acting IL-2 Superkine, Prevents Metastasis, Protects Against Tumor Rechallenges and Provides Long-Term Survival in an Orthotopic Model of Breast Cancer

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2024 San Antonio Breast Cancer Symposium (SABCS)

Neoadjuvant Administration of MDNA11, A Long-Acting IL-2 Superkine, Prevents Metastasis, Protects Against Tumor Rechallenges and Provides Long-Term Survival in an Orthotopic Model of Breast Cancer

Neoadjuvant Administration of MDNA11, A Long-Acting IL-2 Superkine, Prevents Metastasis, Protects Against Tumor Rechallenges and Provides Long-Term Survival in an Orthotopic Model of Breast Cancer

Source

2024 San Antonio Breast Cancer Symposium (SABCS)

Updated Safety and Efficacy Results from the First-in-Human Study of MDNA11 (ABILITY-1), a Next Generation ‘Beta-Enhanced Not-Alpha’ IL-2 Superkine, Show Single-Agent Activity in Patients with Advanced Solid Tumors

Updated Safety and Efficacy Results from the First-in-Human Study of MDNA11 (ABILITY-1), a Next Generation ‘Beta-Enhanced Not-Alpha’ IL-2 Superkine, Show Single-Agent Activity in Patients with Advanced Solid Tumors

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Immunotherapy Bridge 2024

Invigorating Effector Immune Cells With Highly Selective IL-2R Agonists and Potential Synergy With Tumor Targeting Therapeutics for Treatment of Glioblastomas

Invigorating Effector Immune Cells With Highly Selective IL-2R Agonists and Potential Synergy With Tumor Targeting Therapeutics for Treatment of Glioblastomas

Invigorating Effector Immune Cells With Highly Selective IL-2R Agonists and Potential Synergy With Tumor Targeting Therapeutics for Treatment of Glioblastomas

Invigorating Effector Immune Cells With Highly Selective IL-2R Agonists and Potential Synergy With Tumor Targeting Therapeutics for Treatment of Glioblastomas

MDNA113, an IL-13Rα2 Tumor Targeting and Conditionally Activatable anti-PD1-IL-2 BiSKIT Shows Enhanced Safety and Potent Therapeutic Efficacy

MDNA113, an IL-13Rα2 Tumor Targeting and Conditionally Activatable anti-PD1-IL-2 BiSKIT Shows Enhanced Safety and Potent Therapeutic Efficacy

Results from Monotherapy Dose Escalation of MDNA11

Results from Monotherapy Dose Escalation of MDNA11

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Source: SITC 2024

Results from ABILITY-1 Monotherapy Dose Escalation and Ongoing Monotherapy Expansion with MDNA11, a Long-acting ‘Beta-enhanced Not-alpha’ IL-2 Superkine, in Patients with Advanced Solid Tumors

Results from ABILITY-1 Monotherapy Dose Escalation and Ongoing Monotherapy Expansion with MDNA11, a Long-acting ‘Beta-enhanced Not-alpha’ IL-2 Superkine, in Patients with Advanced Solid Tumors

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Source: SITC 2024

MDNA113, an IL-13Rα2 Tumor Targeting and Conditionally Activatable anti-PD1-IL-2SK BiSKIT Shows Enhanced Safety and Potent Therapeutic Efficacy

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Promise IL2 Therapy 2024

MDNA209, a High Affinity IL-2β Biased IL-2/IL-15 Super-antagonist, for the Treatment of Autoimmune Diseases

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Promise IL2 Therapy 2024

Phase 2b Study of Bizaxofusp- ASCO Annual Meeting 2024

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ASCO 2024

Results from Monotherapy Dose Escalation of MDNA11, a Long-acting IL-2 Superkine, in a Phase 1/2 Trial Show Evidence of Single-agent Activity in Advanced Solid Tumors

Results from Monotherapy Dose Escalation of MDNA11, a Long-acting IL-2 Superkine, in a Phase 1/2 Trial Show Evidence of Single-agent Activity in Advanced Solid Tumors

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AACR 2024

Results from Monotherapy Dose Escalation of MDNA11

Results from Monotherapy Dose Escalation of MDNA11

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AACR 2024

AACR 2024 - MDNA113

AACR 2024 - MDNA113

Characterization of MDNA113, a Tumor-Targeting Anti-PD1-IL-2 SK Immunocytokine with Conditional Activation to Increase Tolerability and Maximize Efficacy

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2024 AACR

Overall Survival of Recurrent Glioblastoma (rGBM) in Patients on Bizaxofusp (MDNA55), an IL-4R Targeting Toxin – Phase 2b Study

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2023 SNO

Overall Survival of Recurrent Glioblastoma (rGBM) in Patients on Bizaxofusp (MDNA55), an IL-4R Targeting Toxin – Phase 2b Study

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2023 SNO

Interim PK/PD, Safety and Efficacy Data of Monotherapy Dose Escalation of a Phase 1/2 Trial With MDNA11 in Patients With Advanced Solid Tumors

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38th Annual Meeting of the Society for Immunotherapy Cancer (SITC)

Interim PK/PD, Safety and Efficacy Data of Monotherapy Dose Escalation of a Phase 1/2 Trial With MDNA11 in Patients With Advanced Solid Tumors

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38th Annual Meeting of the Society for Immunotherapy Cancer (SITC)

Characterization of a Tumor-targeting and Activatable T-MASK Platform to Enhance Tumor Accumulation and Tolerability of Potent Immune Modulators

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38th Annual Meeting of the Society for Immunotherapy Cancer (SITC)

Characterization of a Tumor-targeting and Activatable T-MASK Platform to Enhance Tumor Accumulation and Tolerability of Potent Immune Modulators

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38th Annual Meeting of the Society for Immunotherapy Cancer (SITC)

Synergistically Engaging a b-Selective IL-2 Agonist with PD-1/PDL-1 Blockade in a Bifunctional Superkine, MDNA223

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023 AACR Special Meeting in Cancer Research: Tumor Immunology and Immunotherapy

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Clinical Update from Phase 1/2 ABILITY Study

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R&D day, 2023

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Planning of a Phase 3 Randomized Controlled Trial Incorporating an External Control Arm

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National Brain Tumor Society, 2023

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Characterization of MDNA132, an IL-13 Decoy Receptor Selective Superkine for Targeted Delivery of Immunotherapies to the Tumor Microenvironment

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American Association for Cancer Research (AACR) Annual Meeting, 2023

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Early Results of an IL-2 Superkine (MDNA11) from the Phase 1/2 ABILITY Study in Advanced Solid Tumors

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2023 Immunotherapy Bridge Conference, 2022

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The Promise of Interlukin-2 Therapy Conference

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The Promise of IL-2 Therapy (Paris, France), 2022

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Co-Stimulation of Adaptive and Innate Immune Cells to Achieve Clinical Benefit with MDNA11, a Long-Acting ‘Betaonly’ IL-2 Super-Agonist

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Cytokine Based Drug Development Summit, 2022

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MDNA11 is a Long-Acting ‘Beta-Only’ IL-2 Agonist Exhibiting Potent Tumor Growth Control in Preclinical Models and Preferential Expansion of NK and CD8+ T Cells in Patients with Advanced Solid Tumors

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Frontiers in Cancer Immunotherapy 2022

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MDNA11 Phase 1/2 ABILITY Study in Advanced Solid Tumors

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12th Annual LifeSci Partners Corporate Access Event, 2022

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MDNA11 is a Long-Acting ‘Beta-Only’ IL-2 Agonist that Demonstrates Safe and Durable Anti-Tumor Immune Response

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AACR-NCI-EORTC Virtual International Conference On Molecular Targets and Cancer Therapeutics, 2021

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Evolutionary IL-2 Superkines: Past, Present and Future

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Next-Gen Cytokine Therapeutics Summit, 2021

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MDNA55 survival in recurrent glioblastoma ("rGBM") patients expressing the interleukin-4 receptor ("IL4R") as compared to a matched synthetic control

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2021

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Modulation of Immune Responses to Cancer With Bi-specific IL-2/IL-13 Superkines

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American Association for Cancer Research (AACR) Annual Meeting, 2022

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Designer cytotoxins

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Cytokine-Based Cancer Immunotherapies Summit, 2021

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MDNA55 for the Treatment of Recurrent Glioblastoma Multiforme

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KOL day, 2020

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MDNA55, an IL4-Guided Toxin in Recurrent GBM: Phase 2b Results and Use of an External Control Arm in a Registration Trial

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3rd Annual Glioblastoma Drug Development Summit, 2020

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Designer Superkines: Modulating Immune Cells of Choice

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Next-Gen Cytokine Therapeutics Summit, 2020

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In vitro and in vivo characteristics of MDNA11: A long-acting 'Beta-only' IL-2 Superkine in syngeneic mice tumor models and non-human primates

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ASCO, 2020

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IL-2 Superkine, MDNA19, Non-Human Primate Study

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webcast, 2020

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Using a Multi-pronged Approach to Treating Recurrent GBM – Overcoming the Tumor and its Microenvironment

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Inaugural Glioblastoma Drug Development Annual Summit, 2019

Results from Monotherapy Dose Escalation of MDNA11

Results from Monotherapy Dose Escalation of MDNA11

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Source: SITC 2024

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